Challenges and Opportunities for Respiratory Syncytial Virus Vaccines

<p>Part I  Virology,  Pathogenesis, and Clinical and Epidemiological Features of Disease</p><p> </p><p>Respiratory Syncytial Virus: Virology, Reverse Genetics, and Pathogenesis of Disease</p><p>Peter L. Collins, Rachel Fearns, and Barney S. Graham</p><p> </p><p>Clinical and Epidemiologic Features of Respiratory Syncytial Virus<br>Caroline B. Hall, Eric A. F. Simőes, and Larry J. Anderson</p><p> </p><p>Influence of Respiratory Syncytial Virus Strain Differences on Pathogenesis and Immunity</p><p>José A. Melero and Martin L. Moore</p><p> </p><p>Structure and Function of Respiratory Syncytial Virus Surface Glycoproteins</p><p>Jason S. McLellan, William C. Ray and Mark E. Peeples</p><p> </p><p>Respiratory Syncytial Virus and Reactive Airway Disease</p><p>Matthew T. Lotz, Martin L. Moore, and R. Stokes Peebles, Jr.</p><p> </p><p> </p><p>Part II  Host Response to Infection and Genetics of Disease</p><p> </p><p>Human Genetics and Respiratory Syncytial Virus Disease: Current Findings and Future Approaches</p><p>Eun Hwa Choi, Hoan Jong Lee, and Stephen J. Chanock</p><p> </p><p>Innate Immune Responses to Respiratory Syncytial Virus Infection </p><p>Sumanta Mukherjee and Nicholas W. Lukacs</p><p> </p><p>The Adaptive Immune Response to Respiratory Syncytial Virus</p><p>Steven. M. Varga and Thomas J. Braciale</p><p> </p><p>Respiratory Syncytial Virus Mechanisms to Interfere with Type 1 Interferons</p><p>Sailen Barik</p><p> </p><p>Host Gene Expression and Respiratory Syncytial Virus Infection</p><p>Ralph A. Tripp, Asuncion Mejias, and Octavio Ramilo</p><p> </p><p>Consequences of Immature and Senescent Immune Responses for Infection with Respiratory Syncytial Virus</p><p>Allison M.W. Malloy, Ann R. Falsey, and Tracy J. Ruckwardt</p><p> </p><p>Part III  Vaccine Platforms and Treatment Options</p><p> </p><p>Respiratory Syncytial Virus Disease:  Prevention and Treatment </p><p>Helen Y.  Chu and Janet A. Englund</p><p> </p><p>Live-Attenuated Respiratory Syncytial Virus Vaccines</p><p>Ruth A. Karron, Ursula J. Buchholz, and Peter L. Collins</p><p> </p><p>Subunit and Virus-Like Particle Vaccine Approaches for Respiratory Syncytial Virus</p><p>Trudy G. Morrison and Edward E. Walsh</p><p> </p><p>Gene-Based Vaccine Approaches for Respiratory Syncytial Virus</p><p>Rebecca J. Loomis and Philip R. Johnson</p><p>Part IV  Animal and Tissue Culture Models of Infection</p><p>Bovine Model of Respiratory Syncytial Virus Infection</p><p>Geraldine Taylor</p><p> </p><p>The Cotton Rat S. hispidus Model of Respiratory Syncytial Virus Infection</p><p>Marina S. Boukhvalova and Jorge C.G. Blanco</p><p> </p><p>The Mouse Model of Respiratory Syncytial Virus Disease</p><p>Peter J. Openshaw</p><p> </p><p>Human Airway Epithelial Cell Cultures for Modeling Respiratory Syncytial Virus Infection</p><p>Raymond J. Pickles</p><p> </p><p>Part V  Conclusions</p><p> </p><p>Challenges and Opportunities for Respiratory Syncytial Virus Vaccines</p><p>Barney S. Graham and Larry J. Anderson</p><p> </p>